CBE colloquia - Molecular Measurement Technologies for Understanding Immune Responses
Supporting the below United Nations Sustainable Development Goals:支持以下聯合國可持續發展目標：支持以下联合国可持续发展目标：
One of the major goals of biomedical research is to understand human physiopathology, so that we can better diagnose, treat, and prevent diseases. Although fundamental research has revealed the basic rules at the molecular and cellular levels, physiopathology as a much more complexed system involves interactions across different dimensions and scales. The measurement and analysis of physiopathology samples faces various problems such as signal complexity, uncontrollable quality, and sample scarcity. In this seminar I focus on technological challenges in biomedical measurement. Using single-cell sequencing and mass spectrometry as examples, I will demonstrate how precise and sensitive methods facilitate the understanding of long-lived plasma cells (Nat Immunol 2022), autoimmune tolerance (Cell Res 2024), and type-2 immune response (Nature 2025).
Jianbin Wang is an associate professor of life sciences at Tsinghua University in Beijing. He obtained his PhD and postdoctoral training at Stanford University (2008-2015). His technology-oriented lab is devoted to the development of novel strategies for quantitative biomedical measurements. He would like to bring the precision measurement tradition from analytical chemistry to molecular and cellular physiology, hoping to make discoveries that were previously unreachable. So far he has applied new methods on studying tumorigenesis, viral evolution and immune responses, which were recognized by the Chinese Preventive Medicine Association Science and Technology Award and the IADR/AADOCR William J Gies Award.