Guest Seminar - Visualization and Application of Acoustic Interactions with Cells and Tissues
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Acoustic waves are one of the key physical energy modalities used in medicine. While low-energy acoustic waves are employed in ultrasound imaging, and high-energy applications include high-intensity focused ultrasound (HIFU) and shockwave lithotripsy, mild ultrasound and shockwave stimulation have been shown to promote physiological effects such as angiogenesis and bone growth. However, the underlying interactions between acoustic waves and biological tissues remain incompletely understood. To visualize these interactions, we have developed an ultrafast imaging technique capable of capturing dynamic phenomena on the picosecond to femtosecond timescale.
In this talk, I will begin with an overview of acoustic wave–tissue interactions as the foundation of our study. I will then introduce our ultrafast imaging technique, Sequentially Timed All-Optical Mapping Photography (STAMP), along with several application examples. Also I will present our investigation into how shockwaves influence cell membrane permeability. I will conclude with a discussion of future directions and open challenges in this area of research.
Keiichi Nakagawa received his Ph.D. (Engineering) from The University of Tokyo in 2014. He worked as a postdoc at Univ. Tokyo in 2024, a postdoc at MIT in 2015, assistant professor at Univ. Tokyo in 2016, and lecturer at Univ. Tokyo from 2017 to 2023. He is currently an associate professor at the Dept. of Bioengineering, and Dept. of Precision Engineering at Univ. of Tokyo. He has been awarded the Young Scientists' Prize by the Minister of Education, Culture, Sports, Science and Technology, Japan. His research focuses on biomedical applications based on light and acoustic waves and ultrafast imaging techniques.