ECE Seminar - Biomimetic Approaches to Artificial Olfaction

11:00am - 12:30pm
Room 2302 (lift 17/18), Academic Building


The mechanism by which biological chemosensory systems detect, recognize, and discriminate complex mixtures of chemicals has stimulated interest for the development of electronic analogues of olfaction. The principle of combinatorial selectivity has been the main paradigm for the development of electronic noses. This concept is taken from the biological system where generally individual olfactory receptors are not highly selective for a given odorant. Thus, odorants and responses across large numbers of receptors are encoded in combinatorial patterns whose interpretation leads to the odorant identification. Conventional approaches to machine olfaction are limited due to the types of gas sensors currently commercially available. Most of these are hampered by their lack of selectivity, sensitivity to environmental disturbances, drift, and noise. Achievement of robust sensing and reliable systems even with sophisticated signal and data processing approaches has been limited despite decades of development of electronic nose technology.  A paradigm shift is now occurring to overcome these problems. A biomimetic approach to so called “electronic noses” has been adopted where increased understanding of biological chemical sensing can provide new insights into the design of artificial sensing systems. Olfactory receptor proteins and soluble Odorant-binding proteins (OBPs) can now be cloned, modified, and immobilized onto a variety of transducers and several researchers worldwide are now demonstrating the benefits of using these biorecognition elements. We focus on OBPs that are a family of proteins found in chemosensory organs of vertebrates and insects and are associated with detection and release of chemical stimuli. We show that an array of biosensors could be easily constructed based on immobilization of OBPs on to suitable transducers 1,2. Using quartz crystal microbalance platforms, surface acoustic wave devices, or electrochemically gated field effect transistors as a transduction element, it is possible to detect and measure quantitatively concentrations of volatile analytes at parts per million concentrations in air 3,4 and nanomolar concentrations in aqueous solution5. Examples will be given of practical applications of such devices in the field for environmental, security and medical applications.


Keywords: Odour Sensing, Biomimetic Devices, Odorant Binding Proteins, Electronic Noses


1. Pelosi P, Mastrogiacomo R, Iovinella I, Tuccori E, Persaud KC. Structure and biotechnological applications of odorant-binding proteins. Appl Microbiol Biotechnol. 2014;98(1):61–70.

2. Scorsone E, Manai R, Ricatti MJ, Redaelli M, Bergonzo P, Persaud KC, et al. Major urinary proteins on nanodiamond-based resonators toward artificial olfaction. IEEE Sens J. 2016;16(17):6543–50.

3. Nardiello M, Scieuzo C, Salvia R, Farina D, Franco A, Cammack JA, et al. Odorant binding proteins from Hermetia illucens: potential sensing elements for detecting volatile aldehydes involved in early stages of organic decomposition. Nanotechnology. 2022;33(20):205501.

4. Manai R, Scorsone E, Rousseau L, Ghassemi F, Abreu MP, Lissorgues G, et al. Grafting odorant binding proteins on diamond bio-MEMS. Biosens Bioelectron. 2014;60:311–7.

5. Mulla MY, Tuccori E, Magliulo M, Lattanzi G, Palazzo G, Persaud K, et al. Capacitance-modulated transistor detects odorant binding protein chiral interactions. Nat Commun. 2015;6(1):1–9.

讲者/ 表演者:
Prof. Krishna Persaud
The University of Manchester, Department of Chemical Engineering, UK

Krishna Persaud, PhD, FRSC, FInstMC, graduated with BSc Hons Biochemistry at the University of Newcastle-upon-Tyne, UK in 1976, MSc in Molecular Enzymology at the University of Warwick, UK, in 1977 and a PhD specialising in olfactory biochemistry in 1980.  He subsequently worked at the University of Newcastle-upon-Tyne, University of Pisa and the Medical College of Virginia extending his knowledge in the Chemical Senses.  He is Professor of Chemoreception at the University of Manchester, Department of Chemical Engineering.  In his career, he has carried out research in chemoreception, crossing disciplines from biological aspects of olfaction to sensor arrays, electronics, signal processing and pattern recognition, and commercial development of artificial olfaction technologies.v He is a current director of Multisensor Systems Ltd, UK.