CBE Colloquia - Programmable Biologics for Redirecting Protein and Cell Fate
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Cell surface proteins are crucial regulators of cell signaling, metabolism, and communication. Their signaling and functions are tightly regulated through processes such as endocytosis, recycling, phosphorylation, and degradation. In this talk, I will introduce antibody and biosensor engineering approaches to elucidate and reprogram membrane protein signaling, trafficking, and function. Examples include targeting epidermal growth factor receptor pathways, key drivers of non-small cell lung cancer and other malignancies; controlling the signaling of G protein-coupled receptors, the largest family of receptors in humans; and uncovering the molecular mechanisms underlying emerging anti-PD-1/anti-VEGF cancer immunotherapies.
Xin Zhou is an Assistant Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at Dana-Farber Cancer Institute. She leads a chemical biology team interested in understanding and engineering cell surface proteins and developing innovative strategies to study and target cancer. Technologies developed by the Zhou lab include transferrin receptor-targeting chimeras (TransTACs) for targeted membrane protein degradation and drug delivery; GPCR-targeting chimeras (GTACs) for antagonizing GPCRs by rewiring their trafficking; Proteolysis Signature Discovery via Yeast Surface Display (PSurf), a scalable platform for profiling tumor and tissue proteolysis and identifying tumor-specific biosensors; and Selective Phosphotyrosine Detection and Rewiring (SPYER), a synthetic signaling platform for real-time sensing, recording, and rewiring of cellular signaling pathways. Before establishing her independent research group, Xin completed her PhD at Stanford University with Michael Lin and her postdoctoral training at UCSF with James Wells.