Public Research Seminar by Advanced Materials Thrust, Function Hub, HKUST(GZ) - Stochastic dynamics in gene networks: methods and applications
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Cellular functions in biological systems are regulated by the underlying gene regulatory networks. How to investigate the global and stochastic transition properties of gene networks is a challenging problem. In this talk, I will present some approaches we recently developed, i.e., the dimension reduction of landscape and transition path approach, to study the stochastic dynamics of gene networks. The basins on the landscape characterize different cell states. The landscape topography in terms of barrier heights between stable states quantifies the global stability of the gene regulatory system. The kinetic paths based on the minimum action principles quantify the transition processes between different cell states. I will also discuss some applications of this approach in specific biological systems, including cell cycle and cancer system.
Dr. Chunhe Li is an associate professor of Shanghai Mathematics Center, at Fudan University. He is also a faculty affiliated with School of Mathematical Sciences and Institute of Brain-Inspired Intelligence Science and Technology at Fudan University. Dr. Li works on the fields including computational biophysics, computational systems biology, gene regulatory networks, data mining, computational neuroscience, etc. He studies the theory and application of stochastic dynamics on gene regulatory network. As the first or corresponding author in above fields, Dr. Li has published more than 30 papers in Journals such as PNAS, Advanced Science, Cancer Research, PLOS Comput Biol. etc. He won the Best Paper Award of the International Consortium of Chinese Mathematicians (ICCM 2020). In 2017, he was awarded the "Thousand Youth Talents Program". He also received a number of grants as PI including National Key R&D Program of China, and National Natural Science Foundation of China.