Multimodal Intelligent Biointerfaces For Translational Neurological Care and Drug Development

Connecting biological measurements with timely intervention remains a central challenge in neurological care and drug development. Addressing this challenge requires biointerfaces that can accommodate soft tissues, capture complementary biological signals, and translate complex measurements into actionable information. This seminar will present our efforts to integrate flexible bioelectronics, multimodal sensing, and intelligent analysis across therapeutic devices and engineered tissue models. For neurological applications, I will introduce our work on intelligent, closed-loop neuromodulation, highlighting how identifying disease-related states and delivering timely intervention can support more responsive therapeutic strategies. These studies also motivate a broader exploration of multimodal biointerfaces for understanding brain activity and evaluating treatment responses. For drug development, I will discuss our efforts to establish engineered tissue models that capture key features of human tissue microenvironments and allow biological responses to be followed over time. With a focus on hepatic injury and fibrotic remodeling, these platforms aim to support mechanistic studies and more informative evaluation of therapeutic candidates.

Beyond direct intervention, neurological care also encompasses how patients interact with their surroundings, creating opportunities for intelligent robots to assist with everyday activities and therapeutic support. Enabling these systems to perceive and respond effectively is an important step toward future care. In this context, I will introduce our flexible optoelectronic computing interface as an intelligent visual system that supports rapid perception and response, alongside an ultrasound-assisted platform that offers therapeutic capabilities for wound care and drug delivery. These complementary directions point toward intelligent care systems that combine responsive interaction with practical therapeutic functions.