Department of Chemistry Seminar - Protein Modification-Mediated Drug Induced Liver Injury of Diosbulbin B
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Speaker: Prof. Zixia HU
Institution: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, China
Hosted By: Professor Simon Wan CHAN
Abstract
The uniqueness and effectiveness of herbal medicines to cure varieties of diseases are evident in their long history of practice. However, their adverse effects remain challenging problems to be solved for safer clinical applications. Dioscorea bulbifera L. (DBL) is a common herbal medicine widely used in China for the treatments of psoriasis, breast lumps, goiters, and lung abscesses. Unfortunately, liver injury caused by using this herb has limited its safe use; numerous hepatotoxicity cases, including death cases, have been documented. Our study established that diosbulbin B (DSB) constitutes the toxic basis underlying the hepatotoxicity of DBL. From the perspective of metabolic activation, we elucidated the toxic mechanism of DSB and demonstrated, for the first time, a causal relationship between the covalent modification of key proteins by the reactive metabolite of DSB and the onset of hepatotoxicity.