Department of Chemistry Seminar - Catalysts: A New Horizon in Asymmetric Catalysis
Supporting the below United Nations Sustainable Development Goals:支持以下聯合國可持續發展目標：支持以下联合国可持续发展目标：
Speaker: Prof. Xumu ZHANG
Institution: Department of Chemistry, Southern University of Science and Technology, China
Hosted by: Prof. Guocheng JIA, Prof. Yangjian Quan
Abstract
Highly efficient and enantioselective hydrogenation is a key generic technology for green drug synthesis. In 2016, Zhang and coworkers creatively introduced ferrocene skeleton into the tridentate ligand and designed and synthesized a new f-amphox ligand, which showed ultra-high activity and enantioselectivity (>1,000,000 TON, 99% ee) in the hydrogenation of ketones. On this basis of amphox, Zhang and coworkers successively developed chiral tridentate ligands f-amphol, f-ampha and f-amphamide based on ferrocene skeleton, as well as electron-rich Heng-PNP based on rigid skeleton. In 2022, Xumu Zhang proposed the concept of ate catalysis (@ catalysis) and a tetradentate ligand based on the ferrocene skeleton, termed as f-phamidol, was developed based on this concept, which can obtain a TON of up to 13,425,000 in asymmetric hydrogenation of ketones. These multidentate ligands have been applied to the green synthesis of many important drugs such as Ezetimibe, Montelukast, Phenylephrine, Nicotine, etc.