Bioengineering Graduate Program - PhD Thesis Presentation - Developing a Comprehensive System for the Mechanism Study of RNA Polymerase in Transcription

10:30am - 12:30pm
Online via ZOOM

As a function unit in the transcription process, RNA polymerase plays a critical part in natural organism metabolism. Over the past few years, the true significance of RNA polymerase in various fields, including diseases, aging, and development, has been increasingly revealed. There have been numerous technical breakthroughs in recent decades, but there are several issues that have gone unnoticed. On the one hand, as far as eukaryote, their mature RNA is usually modified after transcription, which blocks the acquisition of the in situ information for the working RNA polymerase. RNA sequencing technology's current limitations impact mutation detection. In contrast, because RNA viruses' genomes are only made up of RNA, their conserved RNA dependent RNA polymerase (RdRp) provides a deeper understanding of their gene delivery and inhibition mechanisms. However, because of the absence of a high-resolution biomimetic in vitro transcription assay, the studies focus on viral RdRp is particularly constrained. We developed a comprehensive platform for the mechanism study of RNA polymerase in transcription, which includes sequencing technology targeting highly accurate nascent RNA, and a high-resolution biomimetic in vitro transcription assay.

Event Format
Speakers / Performers:
Yuqing WANG
Bioengineering Graduate Program
Language
English
Recommended For
Alumni
Faculty and staff
HKUST Family
PG students
UG students
More Information

Examination Committee:
Prof. Ning Li (Chair)
Prof. Xuhui Huang and Prof. Peter PH Cheung (Supervisors)
Prof. Fei Sun
Prof. Jiguang Wang
Prof. Zhenguo Wu
Prof. Guangyu Zhu, CityU of HK
 

Organizer
Department of Chemical & Biological Engineering
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