Single-crystal III-V compound semiconductors are important building blocks for functional devices due to their high electron mobilities, wide range of bandgaps, and excellent optoelectronic properties. However, current methods to produce their freestanding membranes for heterointegration suffer from slow processes or poor material quality. In this talk, I would like to introduce “remote epitaxy” as an approach to grow and harvest multiple wafer-scale single-crystal membranes by introducing weak van der Waals interfaces between epitaxial layers. This is achieved by directly growing graphene on III-V semiconductors in the MOCVD, which enables alternating growth of graphene and III-V semiconductor epilayers in a single run. Each epilayer in the multi-stack structure is then exfoliated to produce multiple freestanding single-crystal membranes with extremely high throughput from a single wafer. Toward the end of the talk, I will briefly introduce the applications of remote epitaxy for high-resolution LED displays, ultrathin wearable devices, and reconfigurable AI chips.