Department of Chemistry Seminar - Reaction Discovery to Enable Synthesis and Drug Development
Supporting the below United Nations Sustainable Development Goals:支持以下聯合國可持續發展目標：支持以下联合国可持续发展目标：
Speaker: Prof. Daniel P. Furkert
Institution: School of Chemical Sciences and Maurice Williams Centre for Molecular Biodiscovery, The University of Auckland, New Zealand
Hosted by: Prof. Jianwei SUN
Abstract
Our research is founded on fundamental advances in new organic reactions, and downstream collaborations to support target-driven synthesis and drug discovery. This talk will showcase examples from different areas, including our recent skeletal editing research theme. An early unexpected reaction finding led to an entire manifold of azide-enolate cycloaddition-rearrangement processes to enable direct skeletal modification of unmodified carbonyl compounds. Ketones, aldehydes, esters, lactones, amides and ketones undergo [3+2] cycloaddition with azides, followed by rearrangement to give diverse architectures relevant to drug discovery and natural products. Total synthesis work has successfully delivered access to the complex polyketide natural products cordycicadin D and leonuketal. The group also has a longstanding collaboration in neuropharmacology towards allosteric modulators of CNS GPCRs, particularly the cannabinoid CB1 receptor. Recent efforts towards efficient assembly of high Fsp3 scaffolds to support drug candidate preparation and application to DNA-encoded libraries will also be presented.