Speaker: Professor Hideki YORIMITSU
Affiliation: Professor, Department of Chemistry, Kyoto University, Japan
Hosted By: Professor Hugh NAKAMURA
Aromatic rings hold a central position in organic chemistry and govern the fundamental nature of numerous useful compounds. Aromatic rings are stable due to their aromatic resonance energy and thus usually considered as being unbreakable. Compared with exocyclic modifications of aromatic compounds, little is known about endocyclic modifications such as substitutions of endocyclic atoms and atom insertions into the rings through partial disassembly of the cyclic skeletons and subsequent ring reconstruction. For the last decade, we have been interested in developing a series of new synthetic methods to achieve endocyclic modifications of heteroarenes as a game-changing strategy in organic synthesis. I will talk about our endeavors to establish ‘aromatic metamorphosis’, in other words ‘skeletal editing of aromatic rings’, focusing on the transformations of heteroaromatic skeletons.