CHEM Seminar - Chemical Biology of Protein Aggregation in the Stressed Proteome
10:30am - 12:00pm
Room 6602, 6/F (Lifts 31/32), Academic Building, HKUST

Speaker: Professor Xin ZHANG


Institution: Department of Chemistry, Pennsylvania State University


Hosted by: Professor Benzhong TANG


 


Abstract


We are fosucsed on protein misfolding and aggregation that occur in stressed cells with deficient proteostasis. These molecular events have been associated with a variety of diseases that are termed as protein misfolding diseases. Protein aggregation is a multiple step process that involves misfolded soluble and insoluble aggregates. It is unclear which of these conformations could lead to cytotoxicity that is associated with diseases. In this seminar, I will describe how we have developed chemical methodologies that allow the community to visualize and differentiate, in live cells, the many conformations through the process of protein aggregation.

講者/ 表演者:
Professor Xin ZHANG
Department of Chemistry, Pennsylvania State University
語言
英文
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研究生
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化學系
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